![]() Under the microscope, the ends of the blocks look like lines, making skeletal muscle cells appear to have regularly arranged striations. In each cell, the myofibrils are all aligned in the same direction and are parceled into longitudinal blocks (called sarcomeres) of similar lengths. linear gingival erythemaĪ tissue composed of muscle cells (often multinucleated) that contain neatly packed actin and myosin filaments these filaments are arranged in cylindrical bundles called myofibrils. Patients with TAC may develop a life-threatening anemia that requires immediate blood transfusion or partial exchange transfusion. These patients should be warned of the danger of exposure to parvovirus B-19 infection, informed of the early signs and symptoms, and instructed to seek medical consultation promptly if exposure is suspected. Patients with chronic hemolytic anemia may experience transient aplastic crisis (TAC). Most patients require no specific therapy. In addition, mild transient anemia, thrombocytopenia, and leukopenia may develop. Adults may also experience arthralgia and arthritis although these symptoms are less common in children. The rash usually resolves within 1 week but may occur for several weeks when the patient is exposed to heat, cold, exercise, or stress. Several days following initial erythema, a less distinct rash may appear on the extremities and trunk. Facial redness is similar to that which occurs when a child is slapped however, circumoral redness is absent. The characteristic erythema appears about 10 days later. Patients experience a mild, brief illness complaints include fever, malaise, headache, and pruritus. Transmission is thought to be via respiratory secretions from infected patients however, maternal-fetal transmission can occur and hemolytic disease of the newborn may result. ![]() The causative agent is human parvovirus B-19. A mild, moderately contagious disease seen most commonly in school-age children.
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